EARLY GLYCOTOXIN EXPOSURE INDUCES EX-VIVO LEFT VENTRICULAR DYSFUNCTION IN ADULT RATS

The exposure of the fetus/neonate to glycotoxins via placenta or breast milk, such as themethylglyoxal (MG), has been related short- and long-term disorders in its development.The aim this study was evaluate effects early methylglyoxal, duringthe lactation phase, on cardiac parameters at adulthood. All experimental procedures wereapproved by ethics committee animal use UFG (007/21). Eight pregnant rats wereseparated into: vehicle group (VEH); MG group, (60 mg/kg), treatment wascarried out from PN3 PN14. litters were standardized 4 male female pups. AtPN120, hearts mounted a Langendorff apparatus. 10’ basal, 30’ ischemia 30’of reperfusion performed. Intraventricular systolic (ISP) diastolic (IDP) pressure,dP/dt + - recorded. AUC each experiment calculated, results werecompared using two-way ANOVA with Sidak’s post-hoc test. Despite no difference theheart-to-body weight ratio, presented reduced basal LV contractility both male(p<0.01) (p<0.01) offspring. After ischemia, groups still decreasedLV offspring (p<0.05). Glycotoxins during thelactation leads intrinsic adulthood chances survivingischemic events.